Computer systems covers the design and implementation of computer hardware and software, including architecture, operating systems, programming languages, security and networking. Cyberphysical systems combines computer systems with non-computing physical systems, such as vehicles, buildings and power systems.

The computer and cyberphysical systems group at the University of Colorado teaches classes in, conducts research and consults on systems ranging from software radios to program analysis systems and compilers. Most of the systems faculty are co-located in a single large lab with their students. Students and faculty have constructed prototypes including: deployed experimental wireless systems using novel networking technologies; sensor networks for animal tracking; privacy preserving networks; automotive and telematics systems; energy management for computers, vehicles and buildings; and, architectural simulators and programming language infrastructure.